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During Pontiac's Rebellion, native tribes conducted a siege of Fort Pitt for two months until Colonel Henry Bouquet relieved it after the Battle of Bushy Run.
On April 16, 1771, the city's first civilian local government was created as Pitt Township.
Fort Pitt (now Pittsburgh) at the source of the Ohio River became the main base for settlers moving into the Northwest Territory.
The War of 1812 cut off the supply of British goods, stimulating American industry.
A 1769 survey referenced the future city as the "Manor of Pittsburgh".
Both the Colony of Virginia and the Province of Pennsylvania claimed the region under their colonial charters until 1780, when they agreed under a federal initiative to extend the Mason–Dixon line westward, placing Pittsburgh in Pennsylvania.The nation's eighth-largest bank, eight Fortune 500 companies, and six of the top 300 U. law firms make their global headquarters in the Pittsburgh area, while RAND, BNY Mellon, Nova, Fed Ex, Bayer and NIOSH have regional bases that helped Pittsburgh become the sixth-best area for U. After a public campaign the original spelling was officially restored by the United States Board on Geographic Names in 1911.